Research Unit’s Supervisor: Dr. A. Zaghloul

Research Group: A. Nada, M. Hedaya, A. Zaghloul, M. Al-Soraj, Y. Al-Basarah, F. Bandarkar, E. Abraham, S. Abraham, D. Nabeel, V. Thomas, M. Sobhy, R. Al-Kazmi

Research focus areas:

• Pre-formulation and formulation studies to optimize the physicochemical properties of drugs.

• Development of drug delivery systems with modified and targeted release attributes.

• Quality control of pharmaceuticals.

• Bioavailability and pharmacokinetic studies on new drug formulations and marketed products.

• Pharmacokinetic drug interaction studies and pharmacokinetic- pharmacodynamic modeling.

• Technological and biological aspects of drug and gene delivery, endocytosis and cellular delivery of therapeutic macromolecules.

Areas of Collaborations:

• Dissolution enhancement of poorly water-soluble drugs.

• Stability studies of medicinal compounds in pharmaceutical products

• Rectal formulations studies.

• Drug delivery of therapeutic macro-molecules and protein compounds.

• Pharmacokinetic studies.

• Thermodynamics, thermal analysis and nanotechnology studies.

Selected publications:

• Nada, A.H., Zaghloul, A.A., Hedaya, M.A., Khattab, I.S. (2014). Development of Novel Formulations to Enhance in vivo Transdermal Permeation of Tocopherol, Acta Pharmaceutica, 64, 299-309

• Etman, M.,Farid, R., Nada, A.H., Ebian, A., (2013). Formulation and In Vitro Evaluation of Salbutamol Sulphate In Situ Gelling Nasal Inserts, AAPS Pharm SciTech, 14, 713-718

• Zaghloul, A., Abd-Allah, F., Abu-Seada, H., Nada, A., 733 (2013). Stability and Human Bioavailability of Optimized Self-Emulsified Drug Delivery System of Ibuprofen, American Journal of Pharmtech Research 3, 721-733.

• Hedaya M.A., and Helmy S.A. (2013). Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide: An Open-Label, Randomized, Four-Period Crossover Study in Healthy Egyptian Male Volunteers, Clin Therapeutics 35:846-861.

• Farid, R., Etman, Nada, A.H., Ebian, A. (2012) Sodium Alginate Microspheres of Salbutamol Sulphate for Nasal Administration: Formulation and Evaluation, American Journal of Pharmtech Research 2, 1-20

• Farzana Bandarkar, Ibrahim Khattab (2011). Lyophilized Gliclazide-Poloxamer Solid Dispersions: Enhancement of In-Vitro Dissolution and In-Vivo Bioavailability. International Journal of Pharmacy and Pharmaceutical Sciences, 3 (2), 122-127.